CMC News Bulletin 18 May 2026

Singh_Defective Regulated Secretion In Alzheimers

Dear friends,

We would like to share with you the CMC Alumni News Bulletin along with other alumni news. The details mentioned in the email are also available for viewing on the alumni website https://www.cmcvellorealumni.org/

CMC Newsline:

The link for the CMC Newsline dated 18 May 2026 is given below.

https://www.cmch-vellore.edu/wp-content/uploads/sites/14/2026/05/cmc-weekly-news-18-05-2026.pdf

Please click on the link directly (Ctrl + Click) to view the file. Alternatively, if your browser does not open the webpage, you could copy the link from this email and paste it directly into the browser.

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We are happy to share a write up and an article sent to us by Dr. Preman Singh (MBBS batch of 1983):

Based on our previously published experimental work, we have proposed a novel theory regarding the molecular mechanisms of amyloid neurodegeneration.

This theory, which we call “Defective Regulated Secretion”, explains the powerful correlation that exists between the myriad genetic mutations found in amyloidogenic proteins, and the resultant seemingly amplified neurodegeneration outcomes. Essentially, it posits that genetic mutations trigger the traversement of defective intracellular secretory pathways, the cumulative effects of which produce neuropathology, whether currently histologically recognized or not. It also explains the historically vexatious conundrum of why visible beta-amyloid and tau burdens correlate poorly with clinical dementia.

We hope that this will be useful to our CMC colleagues who work in the field of neurodegenerative tauopathies like Alzheimers, Parkinsons, and Frontotemporal Dementia.

Sincerely,

Preman J. Singh

MBBS Batch of 1983

Email: preman.singh@va.gov; psinghmd@hotmail.com

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With regards,

Yours sincerely,

Smitha Jasper

Secretary, CMC Alumni Association